Since you asking a easy question I will assume there is some reason you have doubts.  So you must be talking about a SMART NAV system.  The answer is yes but you loose the screen and all the ifon that shows on it.  Left in place tocover the hole if removed you can replace the PACCAR radio with a normal DIN size radio.  We have a harness for this unique radio system.  We call it the SMARTNAV Harness. 
If this is not your application tyhen the answer again is yes.